Spiolto Respimat in COPD
Spiolto® Respimat® (tiotropium/olodaterol) is Boehringer Ingelheim’s new advance in COPD maintenance therapy.
Spiolto® Respimat® (tiotropium/olodaterol) is Boehringer Ingelheim’s new advance in COPD maintenance therapy.
Spiolto® Respimat® provides significant improvements in lung function, breathlessness, quality of life and reduction of rescue medication use over Spiriva® Respimat®; right from the initial stages when patients need maintenance therapy.1
Spiolto® is administered via Respimat®, which actively** delivers a unique mist, meaning the patient just needs to take a slow deep breath.2-8
Built on tiotropium, the active ingredient in Spiriva® HandiHaler® and Spiriva® Respimat® - the world’s most prescribed COPD maintenance treatment with over 40 million patient-years* of real life experience across all COPD severities
Enhanced by Striverdi® (olodaterol) which was specifically designed to complement the efficacy of Spiriva®
The clinical course of COPD and the TOviTO® clinical trial programme
The >15,000 patient TOviTO® Phase III clinical trial programme has been designed to evaluate the effect of Spiolto® Respimat® on many of these important elements in the clinical course of COPD.
Efficacy and safety results from TONADO® 1&2: the pivotal Phase III trials for Spiolto® Respimat®
Data from the pivotal Phase III TONADO® trials show Spiolto® Respimat® provides1*… The importance of immediate COPD management
The importance of immediate COPD management
Further data from TONADO®1&2
Footnotes
‡ Figure adapted from Tantucci C, Modina D. Int J Chron Obstruct Pulmon Dis 2012 § Improvement in trough FEV1 after 24 weeks of treatment ¶ Results are derived from a post-hoc subgroup analysis of patients by GOLD stages in the TONADO® 1&2 studies (combined dataset). The primary endpoints of the TONADO® studies were: FEV1 AUC0–3, trough FEV1 and SGRQ total score in patients with a history of moderate-to-very severe COPD (GOLD 2–GOLD 4).
Reference
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- Buhl R, Abrahams R, Grönke L, et al. Tiotropium Plus Olodaterol Fixed-Dose Combination Therapy Provides Lung Function Benefits when Compared with Tiotropium Alone, Irrespective of Prior Treatment with a Long-Acting Bronchodilator: Post Hoc Analyses Of Two 1-Year Studies. ATS 2015 congress Abstract 64799
- Korn S, Buhl R, Grönke L, et al. Analysis of the Efficacy and Safety of the Fixed-Dose Combination of Tiotropium + Olodaterol in Patients with COPD by Initial Disease Severity. ATS 2015 congress Abstract 64575 ERS 2015 abstract information: 1. D. Singh, Tiotropium + olodaterol fixed-dose combination shows clinically meaningful improvements in quality of life versus placebo. Poster PA2958 presented at the European Respiratory Society International Congress, Amsterdam, Monday, 28 September 2015, 14:45-16:45. 2. K.M. Beeh, ENERGITO: efficacy and safety of once-daily combined tiotropium + olodaterol versus twice-daily combined fluticasone propionate + salmeterol. Poster PA4366 presented at the European Respiratory Society International Congress, Amsterdam, Tuesday, 29 September 2015; 12:50-14:40